Current Opinion in Structural Biology
Current Opinion in Structural Biology contains:
• Over 90 reviews from leading international contributors
• Evaluated reference lists for all articles
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Search and read all issues published since 1994, giving you
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The Current Opinion journals were developed out of the
recognition that it is increasingly difficult for specialists to
keep up to date with the expanding volume of information
published in their subject. In Current Opinion in Structural
Biology, we help the reader by providing in a systematic manner:
1. The views of experts on current advances in structural
biology in a clear and readable form.
2. Evaluations of the most interesting papers, annotated by
experts, from the great wealth of original publications.
Division of the subject into sections
The subject of structural biology is divided into twelve major
sections, each of which is reviewed once a year. Each issue
contains two sections, and the amount of space devoted to each
section is related to its importance.
• Folding and binding • Protein-nucleic acid interactions •
Theory and simulation • Macromolecular assemblages • Nucleic
Acids • Sequences and topology • Membranes • Engineering and
design • Carbohydrates and glycoconjugates • Biophysical methods
• Catalysis and Regulation • Proteins
Selection of topics to be reviewed
Section Editors, who are major authorities in the field, are
appointed by the Editors of the journal. They divide their
section into a number of topics, ensuring that the field is
comprehensively covered and that all issues of current
importance are emphasised. Section Editors commission reviews
from authorities on each topic that they have selected.
Reviews
Authors write short review articles in which they present recent
developments in their subject, emphasising the aspects that, in
their opinion, are most important. In addition, they provide
short annotations to the papers that they consider to be most
interesting from all those published in their topic over the
previous year.
Editorial Overview
Section Editors write a short overview at the beginning of the
section to introduce the reviews and to draw the reader's
attention to any particularly interesting developments.
Ethics in Publishing: General Statement
The Editor(s) and Publisher of this Journal believe that there
are fundamental principles underlying scholarly or professional
publishing. While this may not amount to a formal 'code of
conduct', these fundamental principles with respect to the
authors' paper are that the paper should: i) be the authors' own
original work, which has not been previously published
elsewhere, ii) reflect the authors' own research and analysis
and do so in a truthful and complete manner, iii) properly
credit the meaningful contributions of co-authors and
co-researchers, iv) not be submitted to more than one journal
for consideration, and v) be appropriately placed in the context
of prior and existing research. Of equal importance are ethical
guidelines dealing with research methods and research funding,
including issues dealing with informed consent, research subject
privacy rights, conflicts of interest, and sources of funding.
While it may not be possible to draft a 'code' that applies
adequately to all instances and circumstances, we believe it
useful to outline our expectations of authors and procedures
that the Journal will employ in the event of questions
concerning author conduct. With respect to conflicts of
interest, the Publisher now requires authors to declare any
conflicts of interest that relate to papers accepted for
publication in this Journal. A conflict of interest may exist
when an author or the author's institution has a financial or
other relationship with other people or organizations that may
inappropriately influence the author's work. A conflict can be
actual or potential and full disclosure to the Journal is the
safest course. All submissions to the Journal must include
disclosure of all relationships that could be viewed as
presenting a potential conflict of interest. The Journal may use
such information as a basis for editorial decisions and may
publish such disclosures if they are believed to be important to
readers in judging the manuscript. A decision may be made by the
Journal not to publish on the basis of the declared conflict.
For more information, please refer to: http://www.elsevier.com/wps/find/authorshome.authors/conflictsofinterest
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How, when and why proteins collapse: the relation to folding
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 19 November 2011Gilad HaranUnfolded
proteins under strongly denaturing conditions are highly
expanded. However, when the conditions are more close to native,
an unfolded protein may collapse to a compact globular structure
distinct from the folded state. This transition is akin to the
coil–globule transition of homopolymers. Single-molecule FRET
experiments have been particularly conducive in revealing the…
Analyzing conformational changes in the transport cycle of EmrE
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 16 November 2011Katherine
Henzler-WildmanThe small multidrug resistance transporters
represent a unique model system for studying the mechanism of
secondary active transport and membrane protein evolution.
However, this seemingly simple protein has been highly
controversial. Recent studies have provided experimental
evidence that EmrE exists as an asymmetric dimer that exchanges
between identical inward-facing…
Proteins: histones and chromatin
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 11 November 2011Patrick Cramer,
Cynthia Wolberger
Recognition of methylated histones: new twists and variations
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 5 November 2011Sepideh
KhorasanizadehHistone tails undergo methylation at their lysines
and arginines. These chemical marks act as traffic signals that
direct activity of chromatin remodeling complexes to appropriate
regions of the genome. A surprisingly diverse group of effector
protein modules in chromatin remodeling complexes and their
associated factors are involved in the recognition of histone…
The chaperone–histone partnership: for the greater good of
histone traffic and chromatin plasticity
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 2 November 2011Maria Hondele, Andreas
G LadurnerHistones are highly positively charged proteins that
wrap our genome. Their surface properties also make them prone
to nonspecific interactions and aggregation. A class of proteins
known as histone chaperones is dedicated to safeguard histones
by aiding their proper incorporation into nucleosomes. Histone
chaperones facilitate ordered nucleosome assembly and…
Electron microscopy studies of nucleosome remodelers
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 29 October 2011Andres E LeschzinerATP-dependent
chromatin remodeling complexes, or remodelers, are large protein
assemblies that use the energy from ATP hydrolysis to
non-covalently modify the structure of nucleosomes, playing a
central role in the regulation of chromatin dynamics. Our
understanding of the mechanism and regulation of this remodeling
activity and the diversity of products that chromatin…
Electron microscopy studies of nucleosome remodelers
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 29 October 2011Andres E LeschzinerATP-dependent
chromatin remodeling complexes, or remodelers, are large protein
assemblies that use the energy from ATP hydrolysis to
non-covalently modify the structure of nucleosomes, playing a
central role in the regulation of chromatin dynamics. Our
understanding of the mechanism and regulation of this remodeling
activity and the diversity of products that chromatin…
Uncovering the intimate relationship between lipids, cholesterol
and GPCR activation
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 28 October 2011Joanne Oates, Anthony
WattsThe membrane bilayer has a significant influence over the
proteins embedded within it. G protein-coupled receptors (GPCRs)
form a large group of membrane proteins with a vast array of
critical functions, and direct and indirect interactions with
the bilayer are thought to control various essential aspects of
receptor function. The presence of cholesterol, in…
Uncovering the intimate relationship between lipids, cholesterol
and GPCR activation
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 28 October 2011Joanne Oates, Anthony
WattsThe membrane bilayer has a significant influence over the
proteins embedded within it. G protein-coupled receptors (GPCRs)
form a large group of membrane proteins with a vast array of
critical functions, and direct and indirect interactions with
the bilayer are thought to control various essential aspects of
receptor function. The presence of cholesterol, in…
Reading the ubiquitin postal code
Publication year: 2011Source: Current Opinion in Structural
Biology, Available online 27 October 2011Jean-François
TrempePolyubiquitin chains are assembled through the formation
of an isopeptide bond between a lysine side-chain or terminal
amino group of a proximal ubiquitin moiety and the carboxy-terminal
of a distal ubiquitin moiety. Protein substrates tagged by
polyubiquitin chains of different linkages undergo different
fates. Many polyubiquitin chain types have been characterized so
far,…
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